Talk:Tetracyclic antidepressant

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Untitled

Are tetracyclic antidepressants based on the same tetracycle as tetracycline? Iridium77 23:48, 16 Feb 2004 (UTC)

No. A quick glance in the Merck Index shows Maprotiline is structurally unrelated to tetracycline. Mirtazepine is another tetracyclic antidepressant that is currently used. ElBenevolente 00:29, 17 Feb 2004 (UTC)

As far as I'm aware Mirtazapine isn't a tetracyclic but falls into the 'novel' or 'atypical' group of antidepressants which also include venlafaxine, reboxetine and nefazodone. - Vaughan 09:29, 17 Feb 2004 (UTC)

Mirtazepine is a tetracyclic AD that is related to Mianserin. It is even acknowledged in the product labeling: http://www.fda.gov/cder/foi/label/2002/20415S9lbl.pdf ElBenevolente 16:38, 17 Feb 2004 (UTC)

Regarding mianserin, should we really say "have been reported in the scientific literature but are not publicly available"? Anyone can walk into a respectable science library and read hundreds of peer-reviewed articles about mianserin. ElBenevolente 17:07, 17 Feb 2004 (UTC)

My bad wording I'm afraid. I meant the drug has been discussed in the scientific literature but the drug is not publically available for use as a medication. Interesting FDA info by the way. So, this article should mention Mirtazepine and should not suffer from my poor english! - Vaughan 17:26, 17 Feb 2004 (UTC)

I recall that mianserin was available in Europe in the past. I didn't look too hard, but I found this reference: "Mianserin (‘Bolvidon’, ‘Norval’) was withdrawn from the UK market after the introduction of mirtazapine" http://www.rcpsych.ac.uk/publications/gaskell/samplechaps/usedrugs5Chap.pdf It may still be available in other countries.ElBenevolente 18:12, 17 Feb 2004 (UTC)

I added a link to the article on Mirtazapine I wrote. I also deleted the "see also" links, as they were all linked to already in the article. I wasn't sure if I went too far on that one, though, so please add those back if you think they should be there. Defenestration 18:37, 18 Mar 2004 (UTC)

I'm not sure that Trazodone is a tetracyclic antidepressant. I'm not an expert by any means, but RxList, for example, specifically says that it's not: http://www.rxlist.com/cgi/generic/traz.htm. Mrfh2k5 00:15, 6 July 2006 (UTC)[reply]

Trazodone and Nefazodone don't belong to the group of tetracyclic antidepressants (http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD00533.txt) I can't say exactly what group they belong to, I only got a book (sorry german "Medizinische Chemie", Steinhilber) that says they form a unique group called dual serotonerg antidepressants, but I didn't find any weblinks for this

Trazodone is most definitely NOT a tetracyclic AD according to the FDA: "Trazodone HCl is an antidepressant chemically unrelated to tricyclic, tetracyclic, or other known antidepressant agents".[1]

setiptiline availability

According to this old, scanned advert for setiptiline, [2] it seems setiptiline was once available. Archive where it was indicated that it was setipiline depicted in the advert is [3]. Is it still available in Japan? 1992 isn't that long ago. Zaphraud 01:20, 4 August 2007 (UTC)[reply]

Amoxapine? Trazodone?

Coudl somebody point out, what portion of their chemical structure allows to classify these as tetracyclics? Amoxapine is tricyclic, trazodone bicyclic.--84.163.110.20 (talk) 16:35, 15 April 2008 (UTC)[reply]